Treatment for unicameral bone cyst in adults
All of the listed options are involved in the development of a malignant tumor with the ability to metastasize EXCEPT increased apoptosis.
Apoptosis is programmed cell death, and tumor cells are known for their decreased rate of apoptosis. The clinical presentation, radiographs, and histology are most consistent with metastatic carcinoma.
Specifically, tumor produced cell media, containing tumor-produced factors like endothelin 1, had the ability to induce osteoblastic bone metastases in a mice treated with this culture media.
In addition, this process was specifically inhibited by treatment with antagonists to endothelin 1, confirming the role of endothelin 1 in osteoblastic metastases.
Metastatic bony lesions that occur distal to the elbows or knees are most likely to occur from primary lung and kidney tumors.
The exact molecular mechanism for this metastatic pattern is not known.
Thus, many authorities recommend arteriography and embolization of the lesion prior to performing any surgery on a suspected renal metastatic lesion.
The goal is to reduce blood loss in patients undergoing surgery for these hypervascular tumors.
Mohammad and Guise describe their cell-culture and mouse experiments which led to this discovery.The pathology slide shows a mixture of glandular cells and bone, representing metastatic gastric cancer.Osteosarcoma, chondrosarcoma, and primary lymphoma of bone lack the presence of glandular cells on histology.This allows for tumor cell sustained growth even after induction of cellular signals known to induce apoptosis in non-neoplastic cells. A 61-year-old female presents with a 6 month history of pain in the left hip and thigh. Serum protein electrophoresis is normal, and a bone scan shows increased uptake in the left femur only. Metastatic carcinoma is the most common cause of a destructive bone lesion in older adults.Bone is the third most common site of metastasis, behind the lung and liver.
Her recommendations include biopsy of all destructive bone lesions without a history of known bone metastatic disease.